The A-10 was designed around the 30 mm GAU-8 Avenger rotary cannon that is its primary armament. The A-10's airframe was designed for durability, with measures such as 1,200 pounds (540 kg) of titanium armor to protect the cockpit and aircraft systems, enabling it to absorb a significant amount of damage and continue flying. The A-10A single-seat variant was the only version built, though one A-10A was converted to an A-10B twin-seat version. In 2005, a program was begun to upgrade remaining A-10A aircraft to the A-10C configuration.

The A-10's official name comes from the Republic P-47 Thunderbolt of World War II, a fighter that was particularly effective at close air support. The A-10 is more commonly known by its nicknames "Warthog" or "Hog".